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6
(28)microRNA调节基因Gene regulation by microRNAs.pdf
(28)microRNA调节基因Gene regulation by microRNAs(28)microRNA调节基因Gene regulation by microRNAs(28)microRNA调节基因Gene regulation by microRNAs
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9
Real-time quantification of microRNAs by stem-loop RT-PCR.pdf
Real-time quantification of microRNAs by stem-loop RT-PCRReal-time quantification of microRNAs by stem-loop RT-PCRReal-time quantification of microRNAs by stem-loop RT-PCR
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  • 顶11
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7
Circulating microRNAs as Novel Minimally Invasive Biomarkers for Breast Cancer.pdf
ORIGINALARTICLESCirculating microRNAs NovelMinimally Invasive Biomarkers forBreast CancerHelen M. He
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21
MICRORNAS - MASTER REGULATORS AS POTENTIAL THERAPEUTICS IN CANCER 2011.pdf
MICRORNAS - MASTER REGULATORS AS POTENTIAL THERAPEUTICS IN CANCER 2011
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5
oscillatory dynamics of double negative feedback loop motif by micrornas.pdf
OscillatoryDynamics DoubleNegativeFeedback Loop Motif MicroRNAsJianweiShen1,, Baojun Miao1, YongXu21
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18
MicroRNAs in crop improvement_ fine-tuners for complex traits.pdf
NATUREPLANTS 17077(2017) DOI:10.1038/npants.2017.77 /naturepants1REVIEW ARTICLEPUBLISH
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5
【英文Nature】microRNAs阻断剂的体内作用(Silencing of microRNAs in vivo with 'antagomirs').pdf
MicroRNAs(miRNAs)areanabundantclassofnon-codingRNAs
【英文Nature】microRNAs阻断剂的体内作用（Silencing of microRNAs in vivo with ‘antagomirs’）
that are believed to be important in many biological processes
1–3
through regulation of gene expression . The precise molecular
functionofmiRNAsinmammalsislargelyunknownandabetter
understanding will require loss-of-function studies in vivo. Here
we show that a novel class of chemically engineered oligonucleo-
tides, termed ‘antagomirs’, are efficient and specific silencers of
endogenous miRNAs in mice. Intravenous administration of
antagomirs against miR-16, miR-122, miR-192 and miR-194
resulted in a marked reduction of corresponding miRNA levels
in liver, lung, kidney, heart, intestine, fat, skin, bone marrow,
muscle, ovaries and adrenals. The silencing of endogenous
miRNAs by this novel method is specific, efficient and long-
lasting. The biological significance of silencing miRNAs with the
use of antagomirs was studied for miR-122, an abunda
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7
The Diagnostic and Therapeutic Application of Circulating microRNAs in Breast Cancer.pdf
The Diagnostic and Therapeutic Application of Circulating microRNAs in Breast Cancer
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4
燕麦microRNAs及其靶基因的生物信息学预测.pdf
燕麦microRNAs及其靶基因的生物信息学预测燕麦microRNAs及其靶基因的生物信息学预测燕麦microRNAs及其靶基因的生物信息学预测
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